Progynova
has estradiol valerate, a prodrug of the natural human estradiol. During the
menopause ovaries decrease producing the estradiol. Although the menopause is a
natural condition, it often results in distressing symptoms that happens due to
lack of the hormones produced by the ovaries. A prescription is required to buy Progynova
Moreover
when the estradiol lacks in body, it results in thinning of the bones. In some
women this effect may be extensive (postmenopausal osteoporosis) resulting in
fractures of the bones in later life.
Progynova
injection is used to substitute the hormone estradiol that the body fails to
create after menopause. The estradiol relieves annoying symptoms such as nervousness,
irritability, dizziness, hot flushes, sweats, sleep disturbances, headaches, as
well as involuntary loss of urine, vaginal dryness and burning, and pain during
sexual intercourse.
If progynova
is used for a longer period, it can cause excessive development of the lining
of the womb and, as a result, can increase the incidence of womb cancer. An additional
administration of a progestogen can be used to reduce this risk. It causes
regular shedding of the lining of the womb and, therefore, menstruation-like
bleeding. If you have not removed the uterus/womb by surgery, your doctor
should recommend a progestogen hormone for you to take while you are using this
medication.
Effects
Administration of
this drug to nursing mothers has brought a reduction in the amount and quality
of the milk. Mothers receiving this drug have been tested which showed estrogens
in their milk. So estradiol should not be administered to a nursing woman. A study was made on geriatric patients where most
women (80%) were new to this hormone therapy.
They were given conjugated
estrogens plus medroxyprogesterone acetate together. They showed a double
increase in the risk of developing dementia. The majority of patients reported
an Alzheimer's disease.
Children who were
treated with a large amount of dose for a longer period accelerated epiphyseal
closure, resulting in short adult stature. Using progynova injection
before the completion of physiologic puberty also experience premature breast
development and vaginal cornification, and may occasionally induce vaginal
bleeding in girls. In boys, this therapy may affect the normal pubertal
process.
More common side effects associated
with progynova are headache, high blood pressure, anxiety, back pain,
breakthrough bleeding, breast tenderness, sinus problems, constipation,
depression, flu-like symptoms, hot flushes, insomnia, indigestion, nausea, neck pain, skin redness
and irritation at the site of the patch, upper respiratory tract infection,
weight increase. When estrogens and progestins were used by postmenopausal
women, it increased the risk of breast cancer.
A number of postmenopausal
women receiving estrogens showed a 2- to 4-fold increase in the risk of
gallbladder disease. There is potential that estrogen therapy may cause severe
hypercalcemia in patients with breast cancer and bone metastases. If it occurs,
use of the drug should be discontinued and suitable measures taken to reduce
the serum calcium level.
There are some adverse
impact has been noticed. But their occurrence time has not been studied. These
are flushed, dry skin; fruit-like breath odor; increased hunger; irritability; abnormal
turning out of cervix; changes in appetite; dull ache or feeling of pressure or
heaviness in legs; fatigue; large amount of triglyceride in the blood; leg
cramps; patchy brown or dark brown discoloration of skin; poor insight and
judgment; problems with memory or speech.
